PORTLAND, Oregon – /PRNewswire/ — People who lose weight soon
after a diagnosis of type 2 diabetes have better control of their blood
pressure and blood sugar, and are more likely to maintain that control even
if they regain their weight, according to a Kaiser Permanente study
published online in Diabetes Care, the American Diabetes Association
journal.
This is the first clinical study to show that benefits remain even if
patients regain their weight. The study followed more than 2,500 adults with type 2 diabetes for four years. Those who lost weight within a
average of 18 months after diagnosis were up to twice as likely to achieve
their blood pressure and blood sugar targets as those who didn’t lose
weight. Those benefits can prevent diabetes-related heart disease,
blindness, nerve and kidney damage, and death.
“Our study shows that early weight loss can reduce the risk factors
that so often lead to diabetes complications and death,” says Dr. Adrianne
Feldstein, MD, MS, the study’s lead author, a practicing physician and an
investigator at Kaiser Permanente’s Center for Health Research in Portland,
Ore. “We’ve known for a long time that weight loss is an important
component in diabetes treatment and prevention. Now it appears there may be a critical window of opportunity following diagnosis in which some lasting gains can be achieved if people are willing to take immediate steps toward lifestyle changes.”
More than 20 million Americans have type 2 diabetes and most of them
are overweight or obese.
Funded by the National Institutes of Health, the four-year study
conducted by Kaiser Permanente in Oregon and Washington followed 2,574 patients with type 2 diabetes between 1997 and 2002. Scientists followed the weight gain and loss patterns of these patients for three years, and then in the fourth year compared glucose control tests and blood pressure readings.
Most patients remained at about the same weight during the first three
years of the study, but a small group of 314 patients lost an average of 23
pounds. This group was more likely to meet blood pressure and glucose
targets during the fourth year even though, by that time, most of them had
regained their weight.
“We don’t know if the initial weight loss increased the body’s
sensitivity to insulin, or if the sustained lifestyle changes were the
reason for the long-term health benefits,” said Gregory A. Nichols, Ph.D.,
a study co-author at Kaiser Permanente’s Center for Health Research. “But
we do know that losing weight reduces the risk factors that often lead to
heart disease, blindness, nerve and kidney damage, amputations, and death in type 2 diabetes patients.”
Although the study didn’t examine specific methods for weight loss,
prior studies conducted at Kaiser Permanente’s Center for Health Research
have demonstrated effective weight loss strategies. One recent study
reported that diabetic patients who had nutritional counseling were about
twice as likely to lose weight. Another study found that people who keep
food diaries lose twice as much weight as those who don’t, and that people
who attend support groups also lose more weight.
This study — The Weight Change in Diabetes and Glycemic and Blood
Pressure Control study — was supported by a grant from National Institute
of Diabetes and Digestive and Kidney Diseases at the National Institutes of
Health. Study authors include: Adrianne C. Feldstein, MD, MS; Gregory A.
Nichols, Ph.D.; David H. Smith, RPh, MHA, Ph.D.; Victor J. Stevens, Ph.D.;
A. Gabriela Rosales, M.S. and Nancy Perrin, Ph.D. of the Kaiser Permanente
Center for Health Research, and Keith Bachman, MD, of the Northwest
Permanente Medical Group.
Weight Loss Tips for People with Pre-Diabetes or Diabetes
